Class: Antiprotozoals, Miscellaneous
- Antiprotozoal Agents
VA Class: AM900
CAS Number: 443-48-1
Brands: Flagyl
Warning
Carcinogenic in mice and rats.
Avoid unnecessary use; reserve for use in approved indications.. (See Uses.)
Introduction
Antibacterial and antiprotozoal;. nitroimidazole derivative.
Uses for metroNIDAZOLE (Systemic)
Bone and Joint Infections
Adjunct for treatment of bone and joint infections caused by Bacteroides, including the B. fragilis group (B. fragilis, B. distasonis, B. ovatus, B. thetaiotaomicron, B. vulgatus).
Endocarditis
Treatment of endocarditis caused by Bacteroides (including the B. fragilis group).
Gynecologic Infections
Treatment of gynecologic infections (including endometritis, endomyometritis, tubo-ovarian abscess, postsurgical vaginal cuff infection) caused by Bacteroides (including the B. fragilis group), Clostridium, Peptococcus niger, or Peptostreptococcus.
Treatment of acute pelvic inflammatory disease (PID); used in conjunction with other anti-infectives. Metronidazole is included in PID regimens to provide coverage against anaerobes.
When a parenteral regimen is indicated for PID, an initial regimen of IV cefoxitin and IV or oral doxycycline is recommended followed by oral doxycycline; if tubo-ovarian abscess is present, some experts recommend that the oral follow-up regimen include metronidazole (or clindamycin) in addition to doxycycline.
When an oral regimen is indicated for PID, an single IM dose of ceftriaxone, cefoxitin (with oral probenecid), or cefotaxime is recommended in conjunction with oral doxycycline (with or without oral metronidazole). Alternatively, if a parenteral cephalosporin is not feasible and the community prevalence and indi..
