Generic name: Miconazole nitrate
Dosage form: vaginal suppositories
Drug classes:Topical antifungals, Vaginal anti-infectives
Medically reviewed by Drugs.com. Last updated on Oct 1, 2020.
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Miconazole Description
Miconazole Nitrate Vaginal Suppositories USP, 200 mg are white to off-white suppositories, each containing the antifungal agent, Miconazole nitrate, USP 1-[2,4-Dichloro-β-[(2,4- dichlorobenzyl)oxy] phenethyl]-imidazole mononitrate, 200 mg, in a hydrogenated vegetable oil base. The molecular formula is C18H14Cl4N2O•HNO3; the molecular weight is 479.14 and the structural formula may be represented as follows:
Miconazole - Clinical Pharmacology
Miconazole nitrate exhibits fungicidal activity in vitro against species of the genus Candida. The pharmacologic mode of action is unknown. Following intravaginal administration of Miconazole nitrate, small amounts are absorbed. Administration of a single dose of Miconazole nitrate vaginal suppositories (100 mg) to healthy subjects resulted in total recovery from the urine and feces of 0.85% (±0
