Migergot Suppository
Generic name:ergotamine tartrate and caffeine
Dosage form: rectal suppository
Drug class:Antimigraine agents
Medically reviewed by Drugs.com. Last updated on Dec 22, 2021.
ERGOTAMINE TARTRATE and
CAFFEINE SUPPOSITORIES USP
(For Rectal Administration)
Rx only
On This Page
WARNING
Serious and/or life-threatening peripheral ischemia has been associated with the coadministration of ergotamine tartrate and caffeine with potent CYP 3A4 inhibitors including protease inhibitors and macrolide antibiotics. Because CYP 3A4 inhibition elevates the serum levels of ergotamine tartrate and caffeine, the risk for vasospasm leading to cerebral ischemia and/or ischemia of the extremities is increased. Hence, concomitant use of these medications is contraindicated.(See alsoCONTRAINDICATIONSandWARNINGSsection)
DESCRIPTION:
Ergotamine Tartrate and Caffeine Suppository
ergotamine tartrate USP 2 mg
caffeine USP 100 mg
Inactive Ingredients: tartaric acid NF, and hard fat NF
Ergotamine Tartrate and Caffeine Suppositories are for rectal administration only.
Ergotamine Tartrate and Caffeine Suppositories are sealed in foil to afford protection from leakage. If an unavoidable period of exposure to heat softens the suppository, it should be chilled in ice-cold water to solidify it before removing the foil.
Migergot Suppository - Clinical Pharmacology
Ergotamine is an alpha adrenergic blocking agent with a direct stimulating effect on the smooth muscle of peripheral and cranial blood vessels and produces depression of central vasomotor centers. The compound also has the properties of serotonin antagonism. In comparison to hydrogenated ergotam...
