Migranal (Nasal)
Generic name:dihydroergotamine (nasal route) [ dye-hye-droe-er-GOT-a-meen ]
Drug class:Antimigraine agents
Medically reviewed by Drugs.com. Last updated on May 22, 2022.
Serious and/or life-threatening peripheral ischemia has been associated with the coadministration of dihydroergotamine with potent CYP3A4 inhibitors including protease inhibitors and macrolide antibiotics. Because CYP3A4 inhibition elevates the serum levels of dihydroergotamine, the risk for vasospasm leading to cerebral ischemia and/or ischemia of the extremities is increased. Hence, concomitant use of these medications is contraindicated .
Commonly used brand name(s)
In the U.S.
- Migranal
- Trudhesa
Available Dosage Forms:
- Spray
Chemical Class: Ergot Alkaloid
Uses for Migranal
Dihydroergotamine nasal spray is used to treat acute migraine headaches with or without aura. Dihydroergotamine is not an ordinary pain reliever. It will not relieve pain other than from migraine headaches.
This medicine is available only with your doctor's prescription.
Before using Migranal
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of dihydroergotamine nasal spray in the pediatric population. Safety and efficacy have not been established.
Geriatric
No information is available on the relationship of age to the effects of dihydroergotamine nasal spray in geriatric patients.
Breastfeeding
Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Almotriptan
- Amprenavir
- Atazanavir
- Azithromycin
- Boceprevir
- Clarithromycin
- Cobi..
