Acetaminophen and diphenhydramine

Generic name: acetaminophen and diphenhydramine [ a-SEET-a-MIN-oh-fen-and-DYE-fen-HYE-dra-meen ]
Brand names: Headache Relief PM, Legatrin PM, Midol PM, Percogesic Original Strength, Tylenol PM, ... show all 27 brands Tylenol Extra Strength PM, Unisom with Pain Relief, Bayer Select Max Strength Night Time Pain, Genapap PM, Mapap PM, Excedrin PM, Excedrin PM Caplet, Sominex Pain Relief Formula, Tylenol Severe Allergy Caplet, Anacin P.M. Aspirin Free, Coricidin Night Time Cold Relief, Tylenol Extra Strength PM Vanilla, Tylenol Sore Throat Nighttime, Tylenol Cold Relief Caplet, Tylenol Cold Relief Nighttime Caplet, Percogesic Extra Strength, Tylenol Cold Relief Nighttime, Tylenol Extra Strength PM Rapid Release Gelcaps, Excedrin PM Express, Night Time Pain, Pain Relief PM Extra Strength, Aceta-Gesic
Dosage forms: oral liquid (1000 mg-50 mg/30 mL); oral tablet (325 mg-12.5 mg; 500 mg-25 mg; 500 mg-38 mg; 500 mg-50 mg)
Drug class:Analgesic combinations

Medically reviewed by Drugs.com on Sep 29, 2020. Written by Cerner Multum.

What is acetaminophen and diphenhydramine?

Acetaminophen is a pain reliever and a fever reducer. Diphenhydramine is an antihistamine.

Acetaminophen and diphenhydramine is a combination medicine used to treat occasional insomnia associated with minor aches and pains. acetaminophen and diphenhydramine is not for use in treating sleeplessness without pain, or sleep problems that occur often.

Acetaminophen and diphenhydramine is also used to treat minor aches and pains such as headache, back pain, joint or muscle pain, tooth pain, or menstrual cramps.

Acetaminophen and diphenhydramine is also used to treat runny nose, sneezing, itchy nose and throat, and pain or fever caused by allergies, the common cold, or the flu.

Acetaminophen and diphenhydramine may also be used for purposes not listed in this medication guide.

Warnings

Use this medicine exactly as directed. An overdose of acetaminophen can damage your liver or cause death. Taking too much diphenhydramine can lead to serious heart problems, seizures, coma, or death.

Do not use this medicine to make a child sleepy. This medicine is not for use in anyone younger than 12 years old.

Ask a doctor or pharmacist before using any other medicine that may contai