Naftifine

Class: Allylamines
ATC Class: D01AE22
VA Class: DE102
Chemical Name: (E)-N-Methyl-N-(3-phenyl-2-propenyl)-1-naphthalenemethanamine hydrochloride
Molecular Formula: C₂₁H₂₁N•HCl
CAS Number: 65473-14-5
Brands: Naftin

Medically reviewed by Drugs.com on Dec 22, 2021. Written by ASHP.

Introduction

Antifungal; synthetic allylamine structurally and pharmacologically related to terbinafine.

Uses for Naftifine

Dermatophytoses

Treatment of tinea corporis (body ringworm) and tinea cruris (jock itch) caused by Epidermophyton floccosum, Microsporum canis†, Trichophyton mentagrophytes, T. rubrum, T. tonsurans, T. verrucosum†, or T. violaceum†.

Treatment of tinea pedis (athlete's foot) or tinea manuum† caused by Epidermophyton floccosum, Microsporum canis†, Trichophyton mentagrophytes, T. rubrum, T. tonsurans, T. verrucosum†, or T. violaceum†.

Topical antifungals usually effective for treatment of uncomplicated tinea corporis and tinea cruris. An oral antifungal may be necessary when tinea corporis or tinea cruris is extensive, dermatophyte folliculitis is present, the infection is chronic or does not respond to topical therapy, or the patient is immunocompromised because of coexisting disease or concomitant therapy.

Topical antifungals usually effective for treatment of uncomplicated tinea pedis. An oral antifungal may be necessary for the treatment of hyperkeratotic areas on the palms and soles, for chronic moccasin-type (dry-type) tinea pedis, and for tinea unguium (fingernail or toenail dermatophyte infections, onychomycosis).

Gel has been used in the treatment of tinea unguium (onychomycosis)†.

Cutaneous Candidiasis†

Treatment of cutaneous candidiasis† caused by Candida albicans. Less active than imidazole derivatives.

Naftifine Dosage and Administration

Administration

Topical Administration

Apply topically to the skin as a cream or gel.

Do not apply to the eye, nose, mouth, or other mucous membranes.

Do not use with occlusive dressings or wrappings, unless otherwise directed by clinician.

Apply a sufficient amount of topical cream or gel; rub gently into the affected area and surrounding skin.

Wash hands after applying.

Dosage

Available as naftifine hydrochloride; dosage expressed in terms of naftifine.

Adults

Dermatophytoses

Tinea Corporis or Tinea Cruris

Cream: Apply once daily for 2–4 weeks.

Gel: Apply twice daily (morning and evening) for 2–4 weeks.

Clinical improvement usually occurs within the first week of treatment. If clinical improvement does .