Naftifine Gel

Generic name: naftifine hydrochloride
Dosage form: gel
Drug class:Topical antifungals

Medically reviewed by Drugs.com. Last updated on May 23, 2022.

Naftifine Gel Description

Naftifine Hydrochloride Gel USP, 1% contains the synthetic, broad-spectrum, antifungal agent naftifine hydrochloride.
Naftifine Hydrochloride Gel USP, 1% is for topical use only.

Naftifine Hydrochloride Chemical Structure

Chemical Name
(E)-N-Cinnamyl-N-methyl-1-naphthalenemethylamine hydrochloride.
Naftifine hydrochloride has an empirical formula of C21H21N•HCl and a molecular weight of 323.86.

Contains
Active Ingredient
Naftifine hydrochloride…. 1%

Inactive Ingredients
Alcohol (52%v/v), carbopol 974P, diisopropanolamine, edetate disodium, polysorbate 80 and purified water.

Naftifine Gel - Clinical Pharmacology

Naftifine hydrochloride is a synthetic allylamine derivative. The following in vitro data are available, but their clinical significance is unknown. Naftifine hydrochloride has been shown to exhibit fungicidal activity in vitro against a broad spectrum of organisms, including Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Epidermophyton floccosum, Microsporumcanis, Microsporum audouini, and Microsporum gypseum; and fungistatic activity against Candida species, including Candidaalbicans. Naftifine Hydrochloride Gel, 1% has only been shown to be clinically effective against the disease entities listed in the INDICATIONS AND USAGE section.

Although the exact mechanism of action against fungi is not known, naftifine hydrochloride appears to interfere with sterol biosynthesis by inhibiting the enzyme squalene 2, 3-epoxidase. This inhibition of enzyme activity results in decreased amounts of sterols, especially ergosterol, and a corresponding accumulation of squalene in the cells.

Pharmacokinetics

In vitro and in vivo bioavailability studies h