Naltrexone and bupropion (Oral)
Medically reviewed by Drugs.com. Last updated on Apr 7, 2022.
Naltrexone hydrochloride/buPROPion hydrochloride is not approved for use in the treatment of major depressant disorder or other psychiatric disorders. Naltrexone hydrochloride/buPROPion hydrochloride contains buPROPion, the same active ingredient as some other antidepressant medications (including, but not limited to, WELLBUTRIN, WELLBUTRIN SR, WELLBUTRIN XL, and APLENZIN). Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term trials. These trials did not show an increase in the risk of suicidal thoughts and behavior with antidepressant use in subjects over age 24; there was a reduction in risk with antidepressant use in subjects aged 65 and older. In patients of all ages who are started on naltrexone hydrochloride/buPROPion hydrochloride, monitor closely for worsening, and for the emergence of suicidal thoughts and behaviors. Advise families and caregivers of the need for close observation and communication with the prescriber. Naltrexone hydrochloride/buPROPion hydrochloride is not approved for use in pediatric patients .
Commonly used brand name(s)
In the U.S.
- Contrave
Available Dosage Forms:
- Tablet, Extended Release
Therapeutic Class: Antiobesity Agent
Pharmacologic Class: Naltrexone
Chemical Class: Bupropion
Uses for naltrexone and bupropion
Naltrexone and bupropion combination is used together with a reduced-calorie diet and proper exercise to help lose weight and keep it off. Naltrexone and bupropion is used in people who are overweight or very overweight and who also have weight-related medical problems.
Naltrexone and bupropion is available only with your doctor's prescription.
Before using naltrexone and bupropion
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For naltrexone and bupropion, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to naltrexone and bupropion or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of naltrexone and bupropion combination in the pediatric population. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of naltrexone and bupropion combination in the elderly. However, elderly patients may be more sensitive to the effects of naltrexone and bupropion and are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving naltrexone and bupropion.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks befo..
