Naproxen and esomeprazole (Oral)
Medically reviewed by Drugs.com. Last updated on Feb 5, 2022.
There is an increased risk of serious and potentially fatal cardiovascular (CV) thrombotic events, myocardial infarction, and stroke with NSAID use, especially with longer durations, a history of CV disease, or risk factors for CV disease. NSAIDs increase the risk of serious and sometimes fatal gastrointestinal (GI) adverse events, which can include bleeding, ulceration, and perforation of the stomach or intestines. The elderly are at increased risk. These GI events can occur at any time without warning. This drug is contraindicated for the treatment of perioperative pain related to CABG surgery .
Commonly used brand name(s)
In the U.S.
- Vimovo
Available Dosage Forms:
- Tablet, Delayed Release
Therapeutic Class: Antirheumatic
Pharmacologic Class: NSAID
Chemical Class: Propionic Acid (class)
Uses for naproxen and esomeprazole
Naproxen and esomeprazole combination is used to relieve the symptoms of ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis in adults and juvenile idiopathic arthritis (JIA) in children. It is used for patients who have an increased risk for stomach ulcers and who need to take a nonsteroidal anti-inflammatory drug (NSAID) for arthritis or ankylosing spondylitis.
Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat pain, inflammation, swelling, stiffness, and joint pain. Esomeprazole is a proton pump inhibitor (PPI) that is used to treat certain conditions where too much acid is produced in the stomach (eg, duodenal and gastric ulcers).
Naproxen and esomeprazole is available only with your doctor's prescription.
Before using naproxen and esomeprazole
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For naproxen and esomeprazole, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to naproxen and esomeprazole or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of naproxen and esomeprazole combination to treat juvenile idiopathic arthritis in children younger than 12 years of age and weighing less than 38 kilograms. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of naproxen and esomeprazole combination in the elderly. However, elderly patients are more likely to have age-related heart, kidney, or stomach problems, which may require caution and an adjustment in the dose for patients receiving naproxen and esomeprazole.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
