Neutrexin
Generic name: trimetrexate glucuronate
Dosage form: for Injection
Drug class:Miscellaneous antibiotics
Medically reviewed by Drugs.com. Last updated on Apr 21, 2022.
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Neutrexin (TRIMETREXATE GLUCURONATE FOR INJECTION) MUST BE USED WITH CONCURRENT LEUCOVORIN (LEUCOVORIN PROTECTION) TO AVOID POTENTIALLY SERIOUS OR LIFE-THREATENING TOXICITIES (SEE PRECAUTIONS AND DOSAGE AND ADMINISTRATION).
Neutrexin Description
Neutrexin is the brand name for trimetrexate glucuronate. Trimetrexate, a 2,4-diaminoquinazoline, non-classical folate antagonist, is a synthetic inhibitor of the enzyme dihydrofolate reductase (DHFR). Neutrexin is available as a sterile lyophilized powder, containing trimetrexate glucuronate equivalent to either 200mg or 25mg of trimetrexate without any preservatives or excipients. The powder is reconstituted prior to intravenous infusion (see DOSAGE AND ADMINISTRATION, RECONSTITUTION AND DILUTION).
Trimetrexate glucuronate is chemically known as 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl] quinazoline mono-D-glucuronate, and has the following structure:
The empirical formula for trimetrexate glucuronate is C19H23N5O3• C6H10O7 with a molecular weight of 563.56. The active ingredient, trimetrexate free base, has an empirical formula of C19H23N5O3 with a molecular weight of 369.42. Trimetrexate glucuronate for injection is a pale greenish-yellow powder or cake. Trimetrexate glucuronate is soluble in water (>50 mg/mL), whereas trimetrexate free base is practically insoluble in water (<0.1 mg/mL). The pKa of trimetrexate free base in 50% methanol/water is 8.0. The logarithm
