Nexavir

Generic name: liver derivative complex
Dosage form: injection
Drug class:Miscellaneous uncategorized agents

Medically reviewed by Drugs.com. Last updated on Jan 24, 2022.

Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here.

DESCRIPTION:

Nexavir ® Injection (liver derivative complex) is a sterile solution containing 25.5mg liver derivative complex per ml in sterile water for injection.

Nexavir ® Injection is composed of peptides and amino acids. The product contains no protein and does not exhibit anti-anemia activity.

Nexavir ® Injection also contains as inactive ingredients: phenol 0.5%, sterile water for Injection, pH is adjusted with hydrochloric acid or sodium hydroxide when necessary.

CLINICAL PHARMACOI.OGY:

The specific action of Nexavir ® is to enhance the resolution of inflammation and edema. In the late 1920's, it was demonstrated that liver was of benefit to patients suffering from acne vulgaris. 1 As a consequence, various techniques were employed for isolating the active "factor" from liver. Studies published in the late 1930's and early 1940's 2,3,4 showed activity in a specially purified liver fraction. During subsequent years, refinements in the isolation of the active material led to the marketing of Nexavir ®.

Initially it was thought that the primary action of Nexavir ® was on the capillaries and precapillary sphincters. However, it is now believed that this effect is a secondary one and that the primary action of Nexavir ® is in response to injury at the cellular level. The capillary changes observed following administration of Nexavir ® appear to be part of a more fundamental anti-inflammatory effect. In the normal animal, no consistent pharmacodynamic action has been demonstrated for Nexavir ®. In particular, there is no effect on systemic blood pressure, no action on the autonomic nervous