Nolix Lotion

Generic name:flurandrenolide
Dosage form: lotion
Drug class:Topical steroids

Medically reviewed by Drugs.com. Last updated on Apr 1, 2022.

Rx Only

Description

Nolix ® Lotion is a potent corticosteroid intended for topical use. Flurandrenolide occurs as white to off-white, fluffy, crystalline powder and is odorless. Flurandrenolide is practically insoluble in water and in ether. One g dissolves in 72 mL of alcohol and in 10 mL of chloroform. The molecular weight of flurandrenolide is 436.52.

The chemical name of flurandrenolide is Pregn-4-ene-3, 20-dione, 6-fluoro-11, 21-dihydroxy-16, 17-[(1-methylethylidene)bis (oxy)]-, (6α, 11β, 16α)-; its empirical formula is C 24H 33FO 6. The structure is as follows:

Each mL of Nolix ® Lotion contains 0.5 mg (1.145 μmol) (0.05%) flurandrenolide in an oil-in-water emulsion base composed of glycerin, cetyl alcohol, stearic acid, glyceryl monostearate, mineral oil, polyoxyl 40 stearate, menthol, benzyl alcohol, and purified water.

Clinical Pharmacology

Flurandrenolide is primarily effective because of its anti-inflammatory, antipruritic and vasocons..