Nystatin and Triamcinolone Ointment
Generic name: nystatin and triamcinolone acetonide
Dosage form: ointment
Drug class:Topical steroids with anti-infectives
Medically reviewed by Drugs.com. Last updated on Mar 1, 2022.
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Nystatin and Triamcinolone Ointment Description
Nystatin and triamcinolone acetonide ointment, USP for dermatologic use contain the antifungal agent nystatin and the synthetic corticosteroid triamcinolone acetonide.
Nystatin is a polyene antimycotic obtained from Streptomyces noursei. It is a yellow to light tan powder with a cereal-like odor, practically insoluble or insoluble in water and in alcohol. Structural formula:
Triamcinolone acetonide is designated chemically as pregna-1,4-diene-3,20-dione, 9-fluoro-11,21-dihydroxy-16,17- [(1-methylethylidene)bis(oxy)]-, (11β,16α)-9-fluoro-11b,16a,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17- acetal with acetone.
The white to cream crystalline powder has a slight odor, is practically insoluble in water, and very soluble in alcohol. Structural formula:
Each gram of nystatin and triamcinolone acetonide ointment, USP provides 100,000 USP nystatin units and 1 mg triamcinolone acetonide USP in an ointment base of mineral oil and white petrolatum.
Nystatin and Triamcinolone Ointment - Clinical Pharmacology
Nystatin exerts its antifungal activity against a variety of pathogenic and nonpathogenic yeasts and fungi by binding to sterols in the cell membrane. The binding process renders the cell membrane incapable of functioning as a selective barrier. Nystatin provides specific anticandidal activity to Candida (Monilia) albicans and other Ca...
