Dosage form: ointment
Drug class:Topical antifungals
Medically reviewed by Drugs.com. Last updated on Jan 1, 2021.
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Nystatin Ointment Description
Nystatin is a polyene antifungal antibiotic drug obtained from Streptomyces nursei
Nystatin Ointment USP, for topical use only, contains 100,000 USP Nystatin Units per gram, in an ointment base of light mineral oil and white petrolatum. The structural formula is as follows:
Molecular Weight 926.13
Molecular Formula C47H75NO17
Nystatin Ointment - Clinical Pharmacology
Pharmacokinetics
Nystatin is not absorbed from intact skin or mucous membrane.
Microbiology
Nystatin is an antibiotic which is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi, including Candida albicans, C. parapsilosis, C. tropicalis, C. guilliermondi, C. pseudotropicalis, C. krusei, Torulopsis glabrata, Tricophyton rubrum, T. mentagrophytes.
Nystatin acts by binding to sterols in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components. On repeated subculturing with increasing concentrations of nystatin, Candida albicans do
