Odefsey

Generic name:emtricitabine, rilpivirine, and tenofovir [ em-trye-SYE-ta-been, RIL-pi-VIR-een, and-ten-OF-oh-vir ]
Brand names: Complera, Odefsey
Drug class:Antiviral combinations

Medically reviewed by Sanjai Sinha, MD. Last updated on Apr 1, 2021.

What is Odefsey?

Odefsey contains a combination of emtricitabine, rilpivirine, and tenofovir. Emtricitabine, rilpivirine, and tenofovir are antiviral medicines that prevent human immunodeficiency virus (HIV) from multiplying in your body. HIV-1 is the virus that causes AIDS (Acquired Immune Deficiency Syndrome).

Odefsey is a prescription medicine that is used to treat Human Immunodeficiency Virus-1 (HIV-1) in people who have never taken HIV medicines before. This medicine is not a cure for HIV or AIDS.

Odefsey is for use in adults and children who are at least 12 years old.

Odefsey should not be taken together with other antiviral medications to treat HIV or AIDS.

Warnings

There are many other drugs that can make Odefsey less effective and should not be used at the same time. Tell your doctor about all your the medicines you use.

Odefsey may cause a serious condition called lactic acidosis. Get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, fast or uneven heart rate, dizziness, or feeling very weak or tired.

If you have hepatitis B you may develop liver symptoms after you stop taking Odefsey. Your doctor may want to check your liver function for several months after you stop using Odefsey.

Before taking Odefsey

You should not take Odefsey if you are allergic to emtricitabine, rilpivirine, or tenofovir.

Do not take Odefsey with other medicines that also contain emtricitabine, rilpivirine, tenofovir, adefovir, or lamivudine.

There are many other drugs that can make rilpivirine less effective and should not be used at the same time:

• dexamethasone;

• St. John's wort;

• tuberculosis medication - rifabutin, rifampin, rifapentine;

• seizure medicine - carbamazepine, oxcarbazepine, phenobarbital, phenytoin; or

• stomach acid reducers - dexlansoprazole, esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole.

To make sure Odefsey is safe for you, tell your doctor if you have ever had:

• kidney disease;

• liver disease (including hepatitis B or C);

• depression or mental illness; or

• long QT syndrome (in you or a family member)./p>

Some people taking tenofovir develop a serio...