Ospemifene

Generic name: ospemifene [ os-PEM-i-feen ]
Brand name: Osphena
Dosage form: oral tablet (60 mg)
Drug class:Selective estrogen receptor modulators

Medically reviewed by Drugs.com on Jan 21, 2022. Written by Cerner Multum.

What is ospemifene?

Ospemifene is used in menopausal women to relieve vaginal dryness and painful sexual intercourse.

Ospemifene may also be used for purposes not listed in this medication guide.

Warnings

You should not use ospemifene if you have: undiagnosed vaginal bleeding, if you will have major surgery, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina.

Do not use if you are pregnant.

Ospemifene may increase your risk of developing a condition that may lead to uterine cancer. Report any unusual vaginal bleeding right away.

Using this medicine can increase your risk of blood clots, stroke, heart attack, or breast cancer.

Before taking this medicine

You should not use this medication if you are allergic to ospemifene, if you are pregnant, or if you have:

• a history of heart attack, stroke, or blood clot;

• unusual vaginal bleeding that a doctor has not checked; or

• any type of breast, uterine, or hormone-dependent cancer.

Some drugs should not be used together with ospemifene. Your doctor may change your treatment plan if you also use:

• bazedoxifene;

• clomiphene;

• fluconazole;

• rifampin;

• tamoxifen;

• toremifene;

• birth control pills; or

• hormone replacement therapy.

Tell your doctor if you have ever had:

• liver disease;

• breast cancer (in you or a family member); or

• risk factors for heart problems or blood clots (such as diabetes, smoking, being overweight, having high blood pressure, high cholesterol, or lupus).

Ospemifene may increase your risk of blood clots, stroke, heart attack, or breast cancer. Talk wit...