Pacritinib (Oral)
Medically reviewed by Drugs.com. Last updated on Dec 13, 2021.
Commonly used brand name(s)
In the U.S.
- Vonjo
Available Dosage Forms:
- Capsule
Therapeutic Class: Antineoplastic Agent
Pharmacologic Class: Tyrosine Kinase Inhibitor
Uses for pacritinib
Pacritinib is used to treat intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis, and post-essential thrombocythemia myelofibrosis. Myelofibrosis is a life-threatening bone marrow problem which is manifested by the following symptoms: enlarged spleen (splenomegaly), severe itching, fever, night sweats, weight loss, bone pain, or unusual tiredness or weakness.
Pacritinib is a kinase inhibitor that works on the immune system.
Pacritinib is available only with your doctor's prescription.
Before using pacritinib
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For pacritinib, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to pacritinib or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of pacritinib in the pediatric population. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of pacritinib in the elderly.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking pacritinib, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using pacritinib with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Apalutamide
- Bepridil
- Boceprevir
- Carbamazepine
- Cisapride
- Clarithromycin
- Cobicistat
- Conivaptan
- Dronedarone
- Enzalutamide
- Fluconazole
- Fosphenytoin
- Idelalisib
- Indinavir
- Itraconazole
- Ketoconazole
- Lopinavir
- Lumacaftor
- Mesoridazine
- Mitotane
- Nefazodone
- Nelfinavir
- Phenytoin
- Pimozide
- Piperaquine
- Posaconazole
- Rifampin
- Ritonavir
- Saquinavir
- Sparfloxacin
- St John's Wort
