Palonosetron (injection)

Generic name: palonosetron (injection) [ PAL-oh-NOE-se-tron ]
Brand name: Aloxi
Dosage form: intravenous solution (0.25 mg/2 mL; 0.25 mg/5 mL)
Drug class:5HT3 receptor antagonists

Medically reviewed by Drugs.com on Dec 2, 2021. Written by Cerner Multum.

What is palonosetron?

Palonosetron is used in adults to prevent nausea and vomiting caused by surgery, or by receiving medicine to treat cancer (chemotherapy).

Palonosetron is used in children as young as 1 month old only to prevent nausea and vomiting caused by cancer medicine.

Palonosetron may also be used for purposes not listed in this medication guide.

Warnings

Before you receive palonosetron, tell your doctor about all your medical conditions or allergies, and all the medicines you are using. Also make sure your doctor knows if you are pregnant or breast-feeding.

Before taking this medicine

You should not be treated with palonosetron if you are allergic to it.

Tell your doctor if you have ever had an allergic reaction to a similar medicine for nausea or vomiting, such as dolasetron (Anzemet) or ondansetron (Zofran).

Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with palonosetron and cause a serious condition called serotonin syndrome.

Tell your doctor if you are pregnant or breast-feeding.

How is palonosetron given?

Palonosetron is given as an infusion into a vein. A healthcare provider will give you this injection.

Palonosetron is usually given 30 minutes before chemotherapy, or right before you are given anesthesia for surgery.

What happens if I miss a dose?

Because you will receive palonosetron in a clinical setting, you are not likely to miss a dose.

What happens if I overdose?

Since palonosetron is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving palonosetron?

Follow your doctor's instructions about any restrictions on food, bever...