Pegvaliase
Generic name: pegvaliase [ peg-VAL-i-ase ]
Brand name: Palynziq
Dosage form: subcutaneous solution (10 mg/0.5 mL; 2.5 mg/0.5 mL; 20 mg/mL)
Drug class:Miscellaneous metabolic agents
What is pegvaliase?
Pegvaliase is used to lower phenylalanine blood levels in adults with phenylketonuria (PKU) not controlled with other treatment.
Pegvaliase is available only from a certified pharmacy under a special program.
Pegvaliase may also be used for purposes not listed in this medication guide.
Warnings
Pegvaliase can cause a serious allergic reaction. Your first dose will be given in a medical setting.
Get emergency medical help if you have signs of an allergic reaction such as hives, itching, dizziness, wheezing, trouble breathing, or swelling in your face or throat. Your doctor may prescribe an epinephrine injection kit to keep with you at all times.
Before taking this medicine
Pegvaliase can cause a serious allergic reaction. Your doctor may prescribe an epinephrine injection kit to use in case you have a severe allergic reaction. Keep this injection kit with you at all times.
Tell your doctor if you think you might be unable to give yourself an emergency epinephrine injection.
Follow your doctor's instructions about using pegvaliase if you are pregnant. Controlling your phenylalanine levels is very important during pregnancy. Your name may be listed on a pregnancy registry to track the effects of pegvaliase on the baby.
Ask a doctor if it is safe to breastfeed while using this medicine.
Not approved for use by anyone younger than 18 years old.
How should I use pegvaliase?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Pegvaliase is injected under the skin. You may be given other medications to help prevent serious side effects or an allergic reaction.
You will receive your first dose in a medical setting to make sure you do not have an allergic reaction.
Read and follow all Instructions for Use. Ask your doctor or pharmacist if you need help.
Prepare an injection only when you are ready to give it. Call your pharmacist if the medicine looks cloudy, has changed colors, or has particles in it.
Do not shake the prefilled syringe or you may ruin the medicine.
Your healthcare provider will show you where to inject pegvaliase. Do not inject into the same place two times in a row.
You may need to have someone with you for at least 1 hour after you inject this medicine at home, to watch you for signs of ...
