Penicillin G
Class: Natural Penicillins
VA Class: AM110
Chemical Name: [2S-(2α,5α,6β)]-3,3-Dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid compd. withN,N′-bis(phenylmethyl)-1,2-ethanediamine (2:1) tetrahydrate
Molecular Formula: (C16H18N2O4S)2•C16H20N2•4H2OC16H18N2O4S•C13H2O•N2O2•H2OC16H18N2O4S•KC16H18N2O4S•Na
CAS Number: 41372-02-5
Brands: Permapen, Pfizerpen
Warning
Penicillin G benzathine (Bicillin L-A, Permapen) penicillin G procaine, and fixed combination of penicillin G benzathine and penicillin G procaine (Bicillin C-R, Bicillin C-R 900/300), are administered by deep IM injection only and should not be injected IV or admixed with other IV solutions.
Inadvertent IV administration of penicillin G benzathine has been associated with cardiorespiratory arrest and death.
Prior to administration of penicillin G benzathine, penicillin G procaine, or fixed combination of penicillin G benzathine and penicillin G procaine, carefully read the warnings, adverse reactions, and dosage and administration sections of the prescribing information.
Introduction
Antibacterial; β-lactam antibiotic; natural penicillin. Available as penicillin G benzathine, penicillin G procaine, penicillin G potassium, and penicillin G sodium.
Uses for Penicillin G
Bone and Joint Infections
Treatment of native vertebral osteomyelitis or prosthetic joint infections caused by susceptible β-hemolytic streptococci† (penicillin G potassium or sodium).
Treatment of native vertebral osteomyelitis or prosthetic joint infections caused by susceptible Enterococcus† (penicillin G potassium or sodium); used with or without an aminoglycoside.
Treatment of native vertebral osteomyelitis or prosthetic joint infections caused by susceptible Cutibacterium acnes† (formerly Propionibacterium acnes) (penicillin G potassium or sodium).
Consult current IDSA clinical practice guidelines available at [Web] for additional information on management of bone and joint infections.
Endocarditis
Treatment of native valve endocarditis or endocarditis involving prosthetic valve or other prosthetic material caused by certain susceptible gram-positive bacteria (penicillin G potassium or sodium).
Treatment of endocarditis caused by susceptible Streptococcus pyogenes (group A β-hemolytic streptococci; GAS), other β-hemolytic streptococci (including groups C, H, G, L, and M), or S. pneumoniae. AHA states IV penicillin G is a reasonable regimen for treatment of endocarditis caused by susceptible...
