Penicillin G benzathine and penicillin G procaine

Generic name: penicillin G benzathine and penicillin G procaine [ PEN-i-SILL-in-G-BEN-za-theen-and-PEN-i-SILL-in-G-PRO-kane ]
Brand names: Bicillin C-R, Bicillin C-R 900/300
Dosage form: intramuscular suspension (600,000 units-600,000 units/2 mL; 900,000 units-300,000 units/2 mL)
Drug class:Natural penicillins

Medically reviewed by Drugs.com on Jun 11, 2021. Written by Cerner Multum.

What is penicillin G benzathine and penicillin G procaine?

Penicillin G benzathine and penicillin G procaine is a combination antibiotic that is used to treat infections caused by bacteria, including strep, pneumonia, and scarlet fever.

Penicillin G benzathine and penicillin G procaine may also be used for purposes not listed in this medication guide.

Warnings

Tell your caregivers right away if you feel light-headed during the injection.

Before taking this medicine

You should not be treated with this medicine if you are allergic to penicillin or procaine.

Tell your doctor if you have ever had:

an allergic reaction to a cephalosporin antibiotic (Keflex, Omnicef, and others);
any type of allergy;
asthma or breathing problems;
a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency;
heart disease; or
kidney disease.

Tell your doctor if you are pregnant or breastfeeding.

How is penicillin G benzathine and penicillin G procaine given?

Penicillin G benzathine and penicillin G procaine is injected into a muscle by a healthcare provider.

This medicine is sometimes given in a single dose. The medicine may also be given every 2 to 3 days until your body temperature is normal for 48 hours.

Keep receiving the medicine even if your symptoms quickly improve. Skipping doses could make your infection resistant to medication.

You may need tests after treatment to make sure your infection has completely cleared.

If you need a medical, dental, or surgical procedure that includes use of a numbing medicine applied to one area of the body (local), tell the doctor ahead of time if you have recently received a penicillin G benzathine and penicillin G procaine injection.