Phenylephrine and Chlorpheniramine Tablets

Generic name: phenylephrine hydrochloride and chlorpheniramine maleate
Dosage form: tablet
Drug class:Upper respiratory combinations

Medically reviewed by Drugs.com. Last updated on Nov 22, 2021.

Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here.

DESCRIPTION:

Nasal Decongestant/Antihistamine sustained-release tablets for oral administration.

Each Phenylephrine Hydrochloride 20 mg / Chlorpheniramine Maleate 4 mg tablet contains:

Phenylephrine Hydrochloride ..... 20 mg
Chlorpheniramine Maleate ..... 4 mg

In addition, this product contains the following as inactive ingredients: Croscarmellose sodium, Dicalcium phosphate dihydrate, Hydroxypropyl methylcellulose, Microcrystalline cellulose, Silicon dioxide, Stearic Acid, Talc.

CLINICAL PHARMACOLOGY:

Phenylephrine Hydrochloride is a sympathomimetic amine, which acts predominately by a direct action on alpha adrenergic receptors. In therapeutic doses, the drug has no effect on the beta adrenergic receptors of the heart. Clinically, Phenylephrine Hydrochloride shrinks swollen mucus membranes, reduces tissue hyperemia, edema, and nasal congestion; and increases nasal airway patency. In therapeutic doses, the drug causes little, if any, central nervous system (CNS) stimulation.

Chlorpheniramine Maleate competitively antagonizes most of the smooth muscle stimulating actions of histamine on the H1receptors of the GI tract, uterus, large blood vessels, and bronchial muscle. It also antagonizes the action of histamine which results in increased capillary permeability and the formation of edema. Chlorpheniramine Maleate is an alkylamine type of antihistamine. This group of antihistamines is among the most active histamine antagonists and is generally effective in relatively low doses. They thereby prevent, but do not reverse, responses mediated by histamine alone. The anticholinergic actions of most antihistamines provide a drying effect on the nasal mucosa. Chlorpheniramine Maleate is not so prone to produce drowsiness and is among the most suitable agents for daytime use, but a significant proportion of pa..