Phoxillum
Generic name: renal replacement solution
Dosage form: renal replacement solution
Medically reviewed by Drugs.com. Last updated on Jan 24, 2022.
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Indications and Usage for Phoxillum
PRISMASOL and Phoxillum solutions are indicated in pediatric and adult patients for use as a replacement solution in Continuous Renal Replacement Therapy (CRRT) to replace plasma volume removed by ultrafiltration and to correct electrolyte and acid-base imbalances.They may also be used in case of drug poisoning when CRRT is used to remove dialyzable substances.
Phoxillum Dosage and Administration
Administration Instructions
Visually inspect PRISMASOL and Phoxillum for particulate matter and discoloration prior to administration.
Administration should only be under the direction of a physician competent in intensive care treatment including CRRT. Use only with extracorporeal dialysis equipment appropriate for CRRT.
The prepared solution is for single patient use only.
Aseptic technique should be used throughout administration to the patient.
Discard any unused solution.
Dosing Considerations
PRISMASOL replacement solutions contain 4 different combinations of active ingredients (8 different products with varying ingredient amounts). Phoxillum replacement solutions contain 2 different combinations of active ingredients (2 different products with varying ingredient amounts). PRISMASOL and Phoxillum are supplied in a two-compartment bag that must be mixed immediately prior to use [see Dosage and Administration (2.3)]:
- Small compartment A (250 mL) containing an electrolyte solution, and
- Large compartment B (4750 mL) containing the buffer solution.
See Table 1 for the concentrations of the active ingredients (after mixing) in these 10 different replacement solutions (total volume is 5 Liters).
