Physostigmine
Generic name: physostigmine [ FYE-so-STIG-meen ]
Brand name: Antilirium
Dosage form: injectable solution (1 mg/mL)
Drug class:Antidotes
What is physostigmine?
Physostigmine affects chemicals in the body that control the signals sent from the nervous system to the muscles to activate muscle movement.
Physostigmine is used to reverse the effects of certain drugs or substances that interfere with this nerve-muscle communication. Such substances include atropine, scopolamine, belladonna, antihistamines, some antidepressants, and other anticholinergic (AN tye KOE lin ER jik) drugs.
Physostigmine may also be used for purposes not listed in this medication guide.
Warnings
In an emergency situation it may not be possible to tell your caregivers about your health conditions. Make sure any doctor caring for you afterward knows you have received physostigmine.
Before taking this medicine
You should not be treated with physostigmine if you are allergic to it, or if you have:
diabetes;
bladder obstruction or other urination problems;
a blockage in your digestive tract (stomach or intestines);
heart disease; or
gangrene (damaged skin and muscle tissue caused by infection or lack of blood supply).
If possible before you receive physostigmine, tell your doctor if:
you have a sulfite allergy;
you have recently taken Ultracet (acetaminophen with tramadol); or
you regularly take bupropion (Wellbutrin, Zyban, Aplenzin, Forfivo, and others).
In an emergency situation it may not be possible to tell your caregivers if you are pregnant or breast-feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received this medicine.
How is physostigmine given?
Physostigmine is injected into a muscle or into a vein through an IV. A healthcare provider will give you this injection.
When injected into a vein, physostigmine must be given slowly.
Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely while you are receiving physostigmine...
