Class: Miotics
VA Class: OP102
CAS Number: 92-13-7
Brands: Isopto Carpine, Pilopine HS
Introduction
Miotic; direct-acting parasympathomimetic agent.
Uses for Pilocarpine, Pilocarpine Hydrochloride, Pilocarpine Nitrate
Open-angle Glaucoma
Reduction of elevated intraocular pressure (IOP) in patients with primary open-angle (chronic simple, noncongestive) glaucoma.
May use concomitantly with other miotics, sympathomimetic agents, β-adrenergic blocking agents, carbonic anhydrase inhibitors, or hyperosmotic agents.
Angle-closure Glaucoma
Reduction of IOP in the emergency treatment of acute (congestive) angle-closure glaucoma prior to surgery. Because it may preclude successful surgery, do not use for long periods prior to surgical treatment.
Lack of response may be caused by paralysis of the iris sphincter by the extremely high IOP; systemic administration of acetazolamide or hyperosmotic solutions (e.g., glycerin or mannitol) may be required.
Ocular Surgery
Reduction of IOP and protection of the lens by causing miosis prior to goniotomy or iridectomy, including laser iridectomy.
May use to control glaucoma which persists after surgery.
Ophthalmologic Examinations
Production of miosis to counteract mydriatic effects of sympathomimetic agents (e.g., phenylephrine) after ophthalmoscopic examinations in glaucoma patients.
Pilocarpine, Pilocarpine Hydrochloride, Pilocarpine Nitrate Dosage and Administration
Administration
Ophthalmic Administration
Avoid contamination of the solution or gel container.
Ophthalmic solutions are preferred when an acute reduction in IOP and/or an intense miotic effect are necessary (e.g., prior to surgery, following ophthalmologic examinations).
Tonometric measurements recommended before and during therapy.
Ophthalmic Solution
Apply topically to the conjunc...
