Poly-Pred

Generic name: prednisolone acetate, neomycin sulfate, polymyxin b sulfate
Dosage form: ophthalmic suspension
Drug class:Ophthalmic steroids with anti-infectives

Medically reviewed by Drugs.com. Last updated on Jul 22, 2021.

sterile

Poly-Pred Description

Poly-Pred® (prednisolone acetate, neomycin sulfate, polymyxin B sulfate ophthalmic suspension, USP) is a topical anti-inflammatory/anti-infective combination product for ophthalmic use with a pH of 5.0 - 7.0 and an osmolality of 260-340 mOsm/kg.

Structural Formulas:

Chemical Name:

Prednisolone acetate: 11β, 17, 21-Trihydroxypregna-1, 4-diene-3, 20-dione 21-acetate.

Neomycin sulfate is the sulfate salt of neomycin B and neomycin C which are produced by the growth of Streptomyces fradiae (Fam. Streptomycetaceae). It has a potency equivalent to not less than 600 micrograms per milligram of neomycin base, calculated on an anhydrous basis.

Polymyxin B sulfate is the sulfate salt of polymyxin B1 and polymyxin B2 which are produced by the growth of Bacillus polymyxa (Prazmowski) Migula(Fam. Bacillaceae). It has a potency of not less than 6,000 polymyxin B units per milligram, calculated on an anhydrous basis.

Contains: Actives: prednisolone acetate (microfine suspension) 0.5%, neomycin sulfate equivalent to 0.35% neomycin base, polymyxin B sulfate 10,000 units/mL. Inactives: polysorbate 80; polyvinyl alcohol; propylene glycol; purified water; sodium acetate; and thimerosal 0.001% (preservative). The pH range is 5.0 - 7.0.

Poly-Pred - Clinical Pharmacology

Corticosteroids suppress the inflammatory response to a variety of agents and they probably delay or slow healing. Since corticosteroids may inhibit the body's defense mechanism against infection, a concomitant antimicrobial drug may be used when this inhibition is considered to be clinically significant in a particular case.

The anti-infective components in Poly-Pred® ophthalmic suspension are included ...