Ponatinib
Generic name: ponatinib [ poe-NA-ti-nib ]
Brand name: Iclusig
Dosage form: oral tablet (10 mg; 15 mg; 30 mg; 45 mg)
Drug classes:BCR-ABL tyrosine kinase inhibitors, Multikinase inhibitors, VEGF/VEGFR inhibitors
What is ponatinib?
Ponatinib is a cancer medicine that interferes with the growth of some cancer cells.
Ponatinibis used in adults to treat a type of blood cancer called chronic myeloid leukemia (CML), or Philadelphia chromosome positive acute lymphoblastic leukemia (ALL).
Ponatinib is usually given after other similar medications have been tried without success.
Warnings
Ponatinib may cause heart or blood vessel problems that could lead to heart attack, stroke, or death.
Call your doctor or get emergency medical help if you have: chest pain spreading to your jaw or shoulder, shortness of breath, dizziness, severe stomach pain, swelling in your legs, sudden numbness or weakness, headache, or problems with vision or speech.
Ponatinib may also harm your liver. Call your doctor right away if you have upper stomach pain with loss of appetite, dark urine, bruising, or yellowing of your skin or eyes.
Before taking this medicine
You should not use ponatinib if you are allergic to it.
To make sure ponatinib is safe for you, tell your doctor if you have ever had:
heart failure, high blood pressure, heart rhythm problems;
long QT syndrome (in you or a family member);
a stroke or blood clot;
diabetes;
bleeding problems;
lactose intolerance (tablets may contain lactose);
pancreatitis; or
if you've had surgery within the past 2 weeks.
You may need to have a negative pregnancy test before starting this treatment.
Ponatinib may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using ponatinib and for at least 3 weeks after your last dose.
This medicine may affect fertility (ability to have children) in women. However, it is important to use birth control to prevent pregnancy because ponatinib can harm an unborn baby.
You should not breastfeed while using ponatinib and for at least 6 days after your last dose.
How should I take ponatinib?
Take ponatinib ...
