Pretomanid
Generic name: pretomanid [ pre-TOE-ma-nid ]
Dosage form: oral tablet (200 mg)
Drug class:Miscellaneous antituberculosis agents
What is pretomanid?
Pretomanid is an antibiotic used in combination with bedaquiline and linezolid to treat extensively drug-resistant tuberculosis in adults.
pretomanid will not treat tuberculosis that is not active (latent), or tuberculosis that affects parts of the body other than the lungs.
Pretomanid may also be used for purposes not listed in this medication guide.
Warnings
Pretomanid must be given in combination with other antibiotic medications and should not be used alone. Follow your doctor's instructions very carefully.
Before taking this medicine
Tell your doctor if you have ever had:
kidney disease;
heart problems;
a seizure;
long QT syndrome (in you or a family member);
HIV; or
low levels of calcium, potassium, or magnesium in your blood.
pretomanid may affect fertility (ability to have children) in men.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether pretomanid will harm an unborn baby. However, having tuberculosis during pregnancy may cause serious complications in both the mother and the baby. The benefit of treating tuberculosis may outweigh any risks to the baby.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.
Pretomanid is not approved for use by anyone younger than 18 years old.
How should I take pretomanid?
Pretomanid must be given in combination with bedaquiline and linezolid and should not be used alone. Use all 3 medicines as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice.
Pretomanid is taken with food and a glass of water. Swallow the tablet whole and do not crush, chew, or break it.
Pretomanid, bedaquiline, and linezolid are usually given for a total of 26 weeks. Your doctor will tell you if you need to use the medicines for longer than 26 weeks.
During the first 2 weeks, all 3 medications are taken daily. During week 3 through week 26, only pretomanid and linezolid are taken daily and bedaquiline is taken 3 times per week, at least 48 hours apart.
You may need to take this drug combinati...
