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Profender Topical Solution
  • Professionals
  • FDA PI

Profender Topical Solution

Generic name: praziquantel and emodepside
Dosage form: FOR ANIMAL USE ONLY

CAUTION: Federal law (U.S.A.) restricts this drug to use by or on the order of a licensed veterinarian.

Topical Solution for the treatment and control of hookworm, roundworm and tapeworm infections in cats and kittens that are at least 8 weeks of age and weigh at least 2.2 lbs (1 kg).

DESCRIPTION:

PROFENDER [1.98% emodepside/7.94% praziquantel] Topical Solution is a clear yellow ready to use solution packaged in single unit dosing applicator tubes for topical (dermal) treatment of cats 8 weeks of age and older and weighing at least 2.2 lbs (1 kg). The formulation and dosage schedule is designed to provide a minimum of 1.36 mg/lb (3 mg/kg) emodepside and 5.45 mg/lb (12 mg/kg) praziquantel based on body weight. Emodepside, a semi-synthetic molecule, is a cyclic depsipeptide. The chemical name is Cyclo [D-2- hydroxypropanoyl-N-methyl-L-leucyl-3-[4-(4- morpholinyl)phenyl]-D-2-hydroxypropanoyl- N-methyl-L-leucyl-D-2-hydroxypropanoyl-Nmethyl- L-leucyl-3-[4-(4-morpholinyl)phenyl]- D-2-hydroxypropanoyl-N-methyl-L-leucyl]. Praziquantel is an isoquinoline cestocide. The chemical name is 2-Cyclohexylcarbonyl- 1,2,3,6,7,11b-hexahydro-4H-pyrazine-2,1-a-isoquinoline- 4-one.

INDICATIONS:

Profender Topical Solution is indicated for the treatment and control of hookworm infections caused by Ancylostoma tubaeforme (adults, immature adults, and fourth stage larvae), roundworm infections caused by Toxocara cati (adults and fourth stage larvae), and tapeworm infections caused by Dipylidium caninum (adults) and Taenia taeniaeformis (adults) in cats.

Profender Topical Solution Dosage and Administration

The recommended minimum dose is 1.36 mg/lb (3 mg/kg) emodepside + 5.45 mg/lb (12 mg/kg) praziquantel as a single topical dose. A single treatment is effective and a second treatment should not be necessary. If re-infection occurs, the product can be re-applied after 30 days.

1. Select the package that correctly corresponds with the body weight of the cat. (See Table below.)

Cat

W...