Promethazine and Phenylephrine
Generic name: promethazine hydrochloride and phenylephrine hydrochloride
Dosage form: oral syrup
Drug class:Upper respiratory combinations
Medically reviewed by Drugs.com. Last updated on May 1, 2022.
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Promethazine and Phenylephrine Description
Promethazine Hydrochloride and Phenylephrine Hydrochloride Syrup is a yellow-orange colored, fruit flavored syrup. Each 5 mL (one teaspoonful), for oral administration contains: Promethazine hydrochloride 6.25 mg; phenylephrine hydrochloride 5 mg. Alcohol 7%.
Inactive Ingredients: Sucrose syrup, sodium benzoate, sodium citrate, propylene glycol, citric acid, ascorbic acid, methylparaben, propylparaben, FD&C Yellow No. 6, natural tangerine extract and purified water.
Promethazine hydrochloride, a phenothiazine derivative, is chemically designated as (±)-10-[2-(Dimethylamino)propyl] phenothiazine monohydrochloride.
Promethazine hydrochloride occurs as a white to faint yellow, practically odorless, crystalline powder which slowly oxidizes and turns blue on prolonged exposure to air. It is soluble in water and freely soluble in alcohol. It has a molecular weight of 320.88, a molecular formula of C17H20N2S • HCl, and the following structural formula:
Phenylephrine hydrochloride is a sympathomimetic amine salt which is chemically designated as (-)-m-Hydroxy-α-[(methyl amino)methyl]benzyl alcohol hydrochloride. It occurs as white or nearly white crystals, having a bitter taste. It is freely soluble in water and alcohol. Phenylephrine hydrochloride is subject to oxidation and must be protected from light and air. It has a molecular weight of 203.67, a molecular formula of C9H13NO2 • HCl, and the following structural formula:
