Prothrombin complex human (Intravenous)
Medically reviewed by Drugs.com. Last updated on Apr 26, 2022.
Patients receiving treatment with vitamin K antagonists (VKAs) may be at increased risk of thromboembolic events (TE) due to underlying disease states. Both fatal and non-fatal arterial and venous thromboembolic complications have been reported. The potential benefits of reversing VKAs should be weighed against the potential risk of TE. Monitor patients receiving prothrombin complex concentrate (human) for signs and symptoms of TE. Resumption of anticoagulation should be carefully considered as soon as the risk of TE outweighs the risk of acute bleeding. Prothrombin complex concentrate (human) may not be suitable in patients with TE within the last 3 months prior to use .
Commonly used brand name(s)
In the U.S.
- Kcentra
Available Dosage Forms:
- Powder for Solution
Therapeutic Class: Hemostatic
Uses for prothrombin complex human
Prothrombin complex concentrate human injection is used to reverse the effects of anticoagulants or blood thinners (eg, warfarin, Coumadin®, Jantoven®) in adult patients with acute major bleeding.
Prothrombin complex human contains coagulation factors II, VII, IX, and X, and proteins C and S. Prothrombin complex human is used to stop bleeding by helping the blood to clot.
Prothrombin complex human is to be given only by or under the supervision of your doctor.
Before using prothrombin complex human
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For prothrombin complex human, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to prothrombin complex human or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of prothrombin complex concentrate human injection in the pediatric population. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of prothrombin complex concentrate human injection in the elderly.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving prothrombin complex human, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclu..
