Provocholine (Inhalation)
Generic name:methacholine (inhalation route) [ meth-a-KOE-leen ]
Drug class:Miscellaneous uncategorized agents
Medically reviewed by Drugs.com. Last updated on Feb 14, 2022.
Severe bronchoconstriction can result from methacholine chloride administration (including the lowest dose). Use of methacholine chloride is contraindicated in pediatric and adult patients with baseline FEV1 less than 60% predicted or adults with FEV1 less than 1.5 L. Use of methacholine chloride is not recommended in patients with clinically apparent asthma or wheezing. If severe bronchoconstriction occurs, reverse immediately with a rapid-acting inhaled bronchodilator agent (beta-agonist) .
Commonly used brand name(s)
In the U.S.
- Provocholine
Available Dosage Forms:
- Powder for Solution
Therapeutic Class: Diagnostic Agent, Bronchial
Pharmacologic Class: Cholinergic System
Uses for Provocholine
Methacholine inhalation is used to help your doctor diagnose bronchial airway hyperreactivity or asthma. This medicine works by narrowing your bronchial airways. The degree of narrowing will be measured by a device called a spirometer. This test is also called the methacholine challenge test.
This medicine is to be given only under the supervision of your doctor.
Before using Provocholine
In deciding to use a diagnostic test, any risks of the test must be weighed against the good it will do. This is a decision you and your doctor will make. Also, other things may affect test results. For this test, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of methacholine inhalation in children younger than 5 years of age. Safety and efficacy have not been established.
Geriatric
No information is available on the relationship of age to the effects of methacholine inhalation in geriatric patients.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this diagnostic test, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusi..
