Prucalopride

Generic name: prucalopride [ proo-KAL-oh-pride ]
Brand name: Motegrity
Dosage form: oral tablet (1 mg; 2 mg)
Drug class:Serotoninergic neuroenteric modulators

Medically reviewed by Drugs.com on Feb 2, 2022. Written by Cerner Multum.

What is prucalopride?

Prucalopride is used to treat chronic idiopathic constipation (constipation without a known cause).

Prucalopride may also be used for purposes not listed in this medication guide.

Warnings

You should not use prucalopride if you have a blockage in your intestines, Crohn's disease, ulcerative colitis, or intestinal perforation.

Before taking this medicine

You should not use prucalopride if you are allergic to it, or if you have:

• a blockage in your intestines;

• severe constipation;

• inflammatory bowel disease (Crohn's disease, ulcerative colitis);

• toxic megacolon; or

• perforation (a hole or tear) of your intestines.

Tell your doctor if you have ever had:

• kidney disease;

• depression;

• a mood disorder; or

• suicidal thoughts.

Tell your doctor if you are pregnant or breast-feeding.

Prucalopride is not approved for use by anyone younger than 18 years old.

How should I take prucalopride?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

You may take prucalopride with or without food.

Store prucalopride in the original container at room temperature, away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose may cause severe diarrhea.

What should I avoid while taking prucalopride?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Prucalopride side effects

Get emergency medical help if you have signs of an allergic reac...