Pulmolite - Technetium Tc99m Albumin Aggregated
Dosage form: injection
Drug class:Radiologic conjugating agents
Medically reviewed by Drugs.com. Last updated on Dec 22, 2021.
On This Page
DESCRIPTION:
Each vial contains a sterile, non-pyrogenic, lyophilized mixture of:
- Albumin Aggregated – 1.0mg
- Albumin Human – 10mg
- Stannous Chloride, Minimum (SnCl2) – 2.4µg
- Stannous Chloride, (SnCl2) – 7.0µg
- Tin Chloride (stannous and stannic), dihydrate, maximum (as SnCl2·2H20) – 0.13mg
- Sodium Chloride – 10mg
The pH of the kit when reconstituted with 5ml of Sodium Chloride Injection is 5.0-8.0. The contents of the vial are lyophilized and stored under sterile filtered air.
The Albumin Human was non-reactive when tested for hepatitis B surface antigen (HB2Ag). The aggregated particles are formed by denaturation of Albumin Human in a heating and aggregation process. Each vial contains 3.6-6.5 million particles. By light microscopy, more than 90% of the particles are between 10 and 90 micrometers, while the typical average size is 15 to 30 micrometers; none is greater than 150 micrometers.
The drug is administered by intravenous injection for diagnostic use after reconstitution with sterile, non-pyrogenic, oxidant-free Sodium Pertechnetate Tc99m Injection. No less than 90% of the pertechnetate Tc99m added to the vial is bound to the aggregates at preparation time and remains bound throughout the 6 hour lifetime of the preparation.
The precise structure of stannous technetium albumin aggregated complex is unknown at this time.
PHYSICAL CHARACTERISTICS
Technetium Tc99m decays by isomeric transition with a physical half-life of 6.02 hours.1 Photons that are useful for detection and imaging studies are listed in Table 1.
| Radiation | Mean %/Disintegration | Mean Energy (keV) |
|
MEDICAL DEPARTMENTS
Cardiology
Pediatrics
Diabetes Care
Pre-natal Care
Ultrasound Echocardiogram
|
