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Pulmozyme
  • Treatments
  • Cystic Fibrosis

Pulmozyme

Generic name:dornase alfa (inhalation) [ DOOR-nase-AL-fa ]
Drug class:Miscellaneous respiratory agents

Medically reviewed by Philip Thornton, DipPharm. Last updated on Aug 9, 2021.

What is Pulmozyme?

Pulmozyme is a synthetic protein that breaks down excess DNA in the pulmonary secretions of people with cystic fibrosis.

Pulmozyme is used in people with cystic fibrosis to thin mucus in the airways. This may help improve lung function and lower the risk of infections.

Pulmozyme is an inhalation solution and is administerd using a nebulizer, a device that turns liquid medicine into a mist.

Warnings

Do not dilute or mix the Pulmozyme inhalation solution with any other drugs in the nebulizer. Mixing the solution with other drugs could lead to changes in the actions of the medications.

Ampules of Pulmozyme do not contain a preservative. Once opened, the entire contents of the ampule must be used or discarded.

Pulmozyme must be stored in the refrigerator between 36 and 46 degrees Fahrenheit (2 and 8 degrees Celsius) and protected from strong light. Keep unused ampules in the protective foil pouch. Pulmozyme should be kept refrigerated during transport. Combined lengths of exposure of the medication to room temperature should not exceed 24 hours.

Before taking this medicine

You should not use Pulmozyme if you are allergic to dornase alfa or other Chinese Hamster Ovary cell products.

Do not give this medicine to a child without medical advice.

Tell your doctor if you are pregnant or breastfeeding.

How should I use Pulmozyme?

Take Pulmozyme exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.

Use Pulmozyme regularly to get the most benefit.

Read and follow all Instructions for Use. Ask your doctor or pharmacist if you need help.

To use the solution with most nebulizers:

  • Pour the medicine into the nebulizer chamber. Attach the mouthpiece or face mask, then attach the chamber to the compressor. Sit upright and place the mouthpiece into your mouth or put on the face mask. Turn on the compressor.

  • Breathe slowly and evenly until there is no more mist and the drug chamber is empty.

  • Clean the nebulizer after each use. On certain nebulizer systems, you may need to change the handset after 90 uses. Follow the directions that came with your nebulizer.

Do not dilute or mix Pulmozyme with any other drugs in the nebulizer.

Tell the doctor if your child has trouble breathing in or out while using the nebulizer.

Each ampule is for one use only. Throw it away after one use, even if there is still medicine left inside.

Store Pulmozyme ampules in the refrigerator, protected from light. Keep unused ampules in the protective foil pouch.

Pulmozyme must be stored in the refrigerator between 36°F to 46°F (2°C to