Arbinoxa Oral Solution
Generic name:carbinoxamine maleate
Dosage form: oral solution
Drug class:Antihistamines
Medically reviewed by Drugs.com. Last updated on May 23, 2022.
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Arbinoxa Oral Solution Description
Carbinoxamine maleate is a histamine-H1 receptor blocking agent.
Each 5 mL (teaspoonful) of oral solution contains 4 mg carbinoxamine maleate and the following inactive ingredients: artificial bubble gum flavor, citric acid (anhydrous), glycerin, methylparaben, propylene glycol, propylparaben, purified water, sodium citrate (hydrous) and sorbitol solution.
Carbinoxamine maleate is freely soluble in water. Its structure is:
2-[(4-chlorophenyl)-2-pyridinylmethoxy]-N, N-dimethylethanamine (Z)-2-butenedioate (1:1)
C16H19ClN2O•C4H4O4
MW = 406.86
Arbinoxa Oral Solution - Clinical Pharmacology
Carbinoxamine maleate is an antihistamine with anticholinergic (drying) and sedative properties. Antihistamines appear to compete with histamine for receptor sites on effector cells.
The pharmacological effects of carbinoxamine maleate after oral absorption have been shown to last approximately 4 hours.
Interactions of carbinoxamine maleate with food or with other drugs and the possibility of cardiac conduction effects on the QT interval have not been studied.
Indications and Usage for Arbinoxa Oral Solution
Carbinoxamine maleate is effective for the symptomatic treatment of:
Seasonal and perennial allergic rhinitis.
Vasomotor rhinitis.
Allergic conjunctivitis due to inhalant allergens and foods.
Mild, uncomplicated allergic skin manifestations of urticaria and angioedema.
Dermatographism.
As therapy for anaphylactic reactions adjunctive to epinephrine and other standard measures after the acute manifestations have been controlled.
Amelioration of the severity of allergic reactions to blood or plasma.
