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Arthrotec
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Arthrotec

Generic name:diclofenac and misoprostoldye-KLOE-fen-ak-and-mye-so-PROST-ole ]
Drug class:Nonsteroidal anti-inflammatory drugs

Medically reviewed by Sophia Entringer, PharmD. Last updated on Jun 7, 2022.

What is Arthrotec?

Arthrotec contains a combination of diclofenac and misoprostol. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing substances in the body that cause pain and inflammation.

Misoprostol reduces stomach acid and replaces protective substances in the stomach that are reduced by NSAIDs. Misoprostol protects the lining of the esophagus, stomach and intestines while taking diclofenac.

Arthrotec is a prescription medicine used to treat osteoarthritis and rheumatoid arthritis in people at high risk for developing stomach or intestinal ulcers.

Arthrotec is supplied as delayed-release tablets containing 50 mg diclofenac sodium and 200 mcg misoprostol or 75 mg diclofenac sodium and 200 mcg misoprostol.

Warnings

Do not use Arthrotec if you are pregnant. Misoprostol can cause birth defects, miscarriage, premature labor, or rupture of the uterus. You must have a negative pregnancy test within 2 weeks before you start taking Arthrotec. You may need to start taking this medicine only on the 2nd or 3rd day of a normal menstrual period. Use effective birth control while you are using Arthrotec.

You should not use Arthrotec if you have active bleeding in your stomach or intestines.

Diclofenac can increase your risk of fatal heart attack or stroke. Do not use Arthrotec just before or after heart bypass su...