Rilonacept (Subcutaneous)

Medically reviewed by Drugs.com. Last updated on Mar 13, 2022.

Commonly used brand name(s)

In the U.S.

• Arcalyst

Available Dosage Forms:

• Powder for Solution

Therapeutic Class: Immunological Agent

Pharmacologic Class: Interleukin-1 Inhibitor

Uses for rilonacept

Rilonacept injection is used to treat cryopyrin-associated periodic syndromes (CAPS), including familial cold autoinflammatory syndrome (FCAS) and Muckle-Wells syndrome (MWS). Rilonacept can help lessen the signs and symptoms of CAPS, including rash, joint pain, fever, and tiredness. It is also used to treat recurrent pericarditis (RP) and reduce the risk of recurrence.

Rilonacept injection is also used to maintain control of symptoms of deficiency of interleukin-1 receptor antagonist (DIRA).

Rilonacept is available only with your doctor's prescription.

Before using rilonacept

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For rilonacept, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to rilonacept or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of rilonacept to treat CAPS or RP in children younger than 12 years of age and to maintain control of symptoms of DIRA in children weighing less than 10 kilograms (kg). Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of rilonacept in the elderly.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking rilonacept, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using rilonacept with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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