Sacituzumab govitecan
Generic name: sacituzumab govitecan [ SAK-i-TOOZ-ue-mab-GOE-vi-TEE-kan ]
Brand name: Trodelvy
Dosage form: intravenous powder for injection (hziy 180 mg)
Drug class:Miscellaneous antineoplastics
What is sacituzumab govitecan?
Sacituzumab govitecan is used to treat HR-negative and HER2-negative (sometimes called triple-negative) breast cancer, after treatment with at least two other cancer medications.
Sacituzumab govitecan is used to treat cancers of the bladder and urinary tract, after treatment with a platinum cancer medicine and an immunotherapy treatment.
Sacituzumab govitecan is used when the cancer has spread to other parts of the body (metastatic) or cannot be removed with surgery.
Sacituzumab govitecan may also be used for purposes not listed in this medication guide.
Warnings
You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, burning when you urinate, a cough, or trouble breathing.
Sacituzumab govitecan commonly causes diarrhea. Severe diarrhea can lead to dehydration, which may require medical treatment.
Tell your doctor right away the first time you have diarrhea while receiving sacituzumab govitecan, or if you have black or bloody stools, if you feel light-headed, if you can't keep liquids down because of vomiting, or if you can't get your diarrhea to stop within 24 hours.
Before taking this medicine
You should not be treated with sacituzumab govitecan if you have ever had a severe allergic reaction to it.
Tell your doctor if you have ever had:
liver disease; or
if you've been told that you carry a gene called UGT1A1*28, which may increase your risk of getting infections while using sacituzumab govitecan.
Sacituzumab govitecan can harm an unborn baby if the mother or the father is using this medicine.
If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using this medicine and for at least 6 months after your last dose.
It may be harder for you to get pregnant while you are using this medicine. You should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.
If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.
Tell your doctor right away if a pregnancy occurs.
