Class: Replacement Preparations
Chemical Name: Selenium dioxide, monohydrate
Molecular Formula: H2O3Se
CAS Number: 7783-00-8
Introduction
Selenium injection is a sterile, nonpyrogenic solution for use as an additive to solutions for total parenteral nutrition (TPN).
Each mL contains selenious acid 65.4 mcg (equivalent to elemental selenium 40 mcg/mL) and water for injection. pH may be adjusted with nitric acid to 1.8 to 2.4.
Uses for Selenious Acid
Selenium has the following uses:
Selenium injection is indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN). Administration of selenium in TPN solutions helps to maintain plasma selenium levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.
Selenious Acid Dosage and Administration
General
Selenium is available in the following dosage form(s) and strength(s):
Selenium injection containing selenious acid 65.4 mcg/mL (equivalent to elemental selenium 40 mcg/mL).
Dosage
Selenium injection provides 40 mcg selenium/mL. For metabolically stable adults receiving TPN, the suggested additive dosage level is 20 to 40 mcg selenium/day. For pediatric patients, the suggested additive dosage level is 3 mcg/kg/day.
In adults with selenium deficiency states resulting from long-term TPN support, selenium as selenomethionine or selenious acid, administered intravenously at 100 mcg/day for a period of 24 and 31 days, respectively, has been reported to reverse deficiency symptoms without toxicity.
Aseptic addition of selenium injection to the TPN solution under laminar flow hood is recommended. Selenium is physically compatible with the electrolytes and other trace elements usually present in amino-acid/dextrose solution used for TPN. Frequent monitoring of plasma selenium levels is suggested as a guideline for subsequent administration. The normal whole blood range for selenium is approximately 10 to 37 mcg/100 mL.
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