Selpercatinib
Generic name: selpercatinib [ SEL-per-KA-ti-nib ]
Brand name: Retevmo
Dosage form: oral capsule (40 mg; 80 mg)
Drug class:Multikinase inhibitors
What is selpercatinib?
Selpercatinib is used to treat a certain type of non-small cell lung cancer in adults.
Selpercatinib is also used to treat certain types of thyroid cancer in adults and children at least 12 years old.
selpercatinib is used when the cancer has spread to other parts of the body (metastatic).
Selpercatinib is used only if your cancer has a specific genetic marker (an abnormal "RET" gene). Your doctor will test you for this gene.
Selpercatinib was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, some people responded to this medicine, but further studies are needed.
Selpercatinib may also be used for purposes not listed in this medication guide.
Warnings
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
Before taking this medicine
You should not use selpercatinib if you have untreated or uncontrolled hypertension (high blood pressure).
Tell your doctor if you have ever had:
liver disease; or
long QT syndrome (in you or a family member).
Both men and women using selpercatinib should use effective birth control to prevent pregnancy. Selpercatinib can harm an unborn baby if the mother or father is using this medicine. Keep using birth control for at least 1 week after your last dose.
Tell your doctor right away if a pregnancy occurs while either the mother or the father is using selpercatinib.
This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because selpercatinib can harm an unborn baby.
Do not breastfeed while using this medicine, and for at least 1 week after your last dose.
How should I take selpercatinib?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Selpercatinib is usually taken every 12 hours.
Take selpercatinib with food if you also use a "proton pump inhibitor" stomach acid medicine such as
