Selumetinib
Generic name: selumetinib [ SEL-ue-MET-i-nib ]
Brand name: Koselugo
Dosage form: oral capsule (10 mg; 25 mg)
Drug class:Multikinase inhibitors
What is selumetinib?
Selumetinib is used to treat neurofibromatosis (a genetic disorder that causes tumors to develop on the nerves) in children at least 2 years old.
Neurofibromatosis may cause tumors in the brain or spinal cord, learning disabilities, tumors on or under the skin, or bone deformities. Plexiform neurofibromas are large tumors that grow from nerves anywhere in the body and may become cancerous later in life.
Selumetinib is for children with plexiform neurofibromas that cannot be surgically removed.
Selumetinib may also be used for purposes not listed in this medication guide.
Warnings
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
Before taking this medicine
Selumetinib should not be given to a child younger than 2 years old.
Tell your doctor if your child has ever had:
heart problems;
vision problems; or
liver problems.
A girl who has entered puberty may need to have a negative pregnancy test before starting this treatment.
Selumetinib can harm an unborn baby if the mother or father is using selumetinib.
Girls who are able to get pregnant should use effective birth control to prevent pregnancy while taking selumetinib.
Boys with female sex partners who are able to get pregnant should also use effective birth control while taking selumetinib.
Keep using birth control for at least 1 week after the last dose of selumetinib.
Tell your doctor right away if a pregnancy occurs while either the mother or the father is using selumetinib.
Do not breastfeed while using this medicine, and for at least 1 week after your last dose.
How should I take selumetinib?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Take selumetinib with a full glass of water on an empty stomach, at least 1 hour before or 2 hours after a meal.
Take the medicine at the same time each day, about every 12 hours. Follow your doctor's dosing instructions very carefully.
Swallow the capsule whole and do not crush, chew, break, or open it.
Tell your doctor if the child taking selumetinib has trouble swallowing the capsule whole.
If you vomit shortly after taking selum...
