Ser-Ap-Es

Generic name:reserpine, hydralazine hydrochloride and hydrochlorothiazide
Dosage form: Combination Tablets
Drug class:Miscellaneous antihypertensive combinations

Medically reviewed by Drugs.com. Last updated on Mar 22, 2022.

C97-38 (Rev. 1/98) 666496

Ser-Ap-Es®

reserpine USP 0.1 mg

hydralazine hydrochloride USP 25 mg

hydrochlorothiazide USP 15 mg

Combination Tablets

Caution: Federal law prohibits dispensing without prescription.

Prescribing Information

WARNING

This fixed-combination drug is not indicated for initial therapy of hypertension. Hypertension requires therapy titrated to the individual patient. It the fixed combination represents the dosage so determined, its use may be more convenient in patient management. The treatment of hypertension is not static but must be reevaluated as conditions in each patient warrant.

DESCRIPTION

Ser-Ap-Es is an antihypertensive-diuretic combination, available as tablets for oral administration. Each tablet contains Serpasil (reserpine USP), 0.1 mg; Apresoline (hydralazine hydrochloride USP), 25 mg; and Esidrix (hydrochlorothiazide USP), 15 mg.

Reserpine is methyl 18β-hydroxy-11,17α-dimethoxy-3β,20α-yohimban-16β-carboxylate 3,4,5-trimethoxybenzoate (ester), and its structural formula is

Reserpine USP, a pure crystalline alkaloid of rauwolfia, is a white or pale buff to slightly yellowish, odorless crystalline powder. It darkens slowly on exposure to light, but more rapidly when in solution. It is insoluble in water, freely soluble in acetic acid and in chloroform, slightly soluble in benzene, and very slightly soluble in alcohol and in ether. Its molecular weight is 608.69.

Hydralazine hydrochloride is 1-hydrazinophthalazine monohydrochloride, and its structural formula is

Hydralazine hydrochloride...