Smallpox and Monkeypox Vaccine Live
Class: Vaccines
Brands: Jynneos
Introduction
Smallpox and monkeypox vaccine live is a live, attenuated, non-replicating virus vaccine produced using modified Vaccinia Ankara-Bavarian Nordic (MVA-BN), an attenuated, non-replicating orthopoxvirus.
Uses for Smallpox and Monkeypox Vaccine Live
Smallpox and monkeypox vaccine live has the following uses:
Smallpox and monkeypox vaccine live is indicated for prevention of smallpox and monkeypox disease in adults 18 years of age and older determined to be at high risk for smallpox or monkeypox infection.
Smallpox and Monkeypox Vaccine Live Dosage and Administration
General
Smallpox and monkeypox vaccine live is available in the following dosage form(s) and strength(s):
Suspension, for subcutaneous use: Single-dose vial containing one 0.5-mL dose.
Dosage
It isessentialthat the manufacturer's labeling be consulted for more detailed information on dosage and administration of this drug. Dosage summary:
Adults
Dosage and Administration
For subcutaneous injection only, preferably into the deltoid.
Administer 2 doses (0.5 mL each) 4 weeks apart.
Cautions for Smallpox and Monkeypox Vaccine Live
Contraindications
None.
Warnings/Precautions
Severe Allergic Reactions
Appropriate medical treatment must be available to manage possible anaphylactic reactions following administration of smallpox and monkeypox vaccine live.
Individuals who experienced a severe allergic reaction following a previous dose of smallpox and monkeypox vaccine live or following exposure to any component of the vaccine may be at increased risk for severe allergic reactions to smallpox and monkeypox vaccine live. The risk for a severe allergic reaction should be weighed against the risk for disease due to smallpox or monkeypox.
Altered Immunocompetence
Immunocompromised individuals, including those receiving immunosuppressive therapy, may have a diminished immune response to smallpox and monkeypox vaccine live.
Because smallpox and monkeypox vaccine live contains non-replicating virus, the vaccine can be used in adults with certain immunodeficiencies or conditions, such as human immunodeficiency virus (HIV) infection or atopic dermatitis.
Limitations of Vaccine Effectiveness
Vaccination with smallpox and monkeypox vaccine live may not protect all recipients.
For primary immunization, smallpox and monkeypox vaccine live is administered in a series of 2 doses given 4 weeks apart; full immunity may not develop until 2 weeks after the second dose.
Specific Populations
Pregnancy
Risk Summary: Available human data on smallpox and monkeypox vaccine live administered to pregnant women are insufficient to inform vaccine-associated risks in pregnancy. All pregnancies have a risk of birth defect, loss, or other adverse outcomes. In the US general population, the estimated background risk of major birth defects and miscar...
