Sodium Acetate

Dosage form: injection, solution, concentrate
Drug classes:Minerals and electrolytes, Urinary pH modifiers

Medically reviewed by Drugs.com. Last updated on May 1, 2021.

Injection, USP

2 mEq/mL

FOR ADDITIVE USE ONLY AFTER DILUTION IN INTRAVENOUS FLUIDS.

Glass Fliptop Vial

DESCRIPTION

Sodium Acetate Injection, USP (2 mEq/mL) is a sterile, nonpyrogenic, concentrated solution of Sodium Acetate in water for injection. The solution is administered after dilution by the intravenous route as an electrolyte replenisher. It must not be administered undiluted. Each mL contains 164 mg of Sodium Acetate (anhydrous) which provides 2 mEq each of sodium (Na+) and acetate (CH3COO-). The solution contains no bacteriostat, antimicrobial agent or added buffer. May contain acetic acid for pH adjustment; the pH is 6.5 (6.0 to 7.0). The osmolar concentration is 4 mOsmol/mL (calc.); specific gravity 1.081.

The solution is intended as an alternative to sodium chloride to provide sodium ion (Na+) for addition to large volume infusion fluids for intravenous use.

Sodium Acetate, USP anhydrous is chemically designated CH3COONa, a hygroscopic powder very soluble in water.

A Pharmacy Bulk Package is a container of a sterile preparation for parenteral use that contains many single doses. The contents are intended for use in a pharmacy admixture program and are restricted to the preparation of admixtures for intravenous infusion.

CLINICAL PHARMACOLOGY

Sodium is the principal cation of extracellular fluid. It comprises more than 90% of total cations at its normal plasma concentration of approximately 140 mEq/liter. The sodium ion exerts a primary role in controlling total body water and its distribution.

Acetate (CH3COO-) is a hyd...