Sodium Citrate Anticoagulant Solution

Generic name: trisodium citrate dihydrate
Dosage form: injection, solution
Drug class:Urinary pH modifiers

Medically reviewed by Drugs.com. Last updated on Dec 22, 2021.

Indications and Usage for Sodium Citrate Anticoagulant Solution

SODIUM CITRATE 4% W/V ANTICOAGULANT SOLUTION USP is intended for use only for the anticoagulation of whole blood as part of automated apheresis procedures. [See Dosage and Administration (2).]

Sodium Citrate Anticoagulant Solution Dosage and Administration

General Dosing Information

SODIUM CITRATE 4% W/V ANTICOAGULANT SOLUTION USP is added to tubing sets during apheresis procedures. The solution bag is connected to the tubing set in an apheresis collection. The recommended dose is determined by the apheresis device and metered into the tubing set by the apheresis device. It is not intended for direct intravenous infusion.

For instructions on the use of the solution with the apheresis device and tubing set, see the device operator's manual.

Administration

• Ensure solution is the SODIUM CITRATE 4% W/V ANTICOAGULANT SOLUTION USP and is within the expiration date.
• Inspect the bag. Do not use if the container is damaged, leaking or if there is any visible sign of deterioration.
• Use only if solution is clear and free of particulate matter.
• Protect from sharp objects.

Directions for connecting the SODIUM CITRATE 4% W/V ANTICOAGULANT SOLUTION USP bag to the apheresis device.

At the prompt to connect anticoagulant to the apheresis device tubing set:

1. Remove the overwrap by pulling down at the notch, and remove the SODIUM CITRATE 4% W/V ANTICOAGULANT SOLUTION USP bag.
2. Before use, perform the following checks [see Warnings and Precautions (5)]:
   • Check for leaks by gently squeezing the bag. If leaks are found, discard the bag.
   • Ensure that the solution is the SODIUM CITRATE 4% W/V ANTICOAGULANT SOLUTION USP and is within the expiration date.
   • Inspect the solution in good light. Bags showing cloudiness, haze, or particulate matter should not be used.
3. Remove the protective cap from the port on the bag.
4. Connect the bag to the apheresis device tubing set using aseptic technique an..