Staticin
Generic name:erythromycin
Dosage form: Topical Solution 1.5%
Drug classes:Topical acne agents, Topical antibiotics
Medically reviewed by Drugs.com. Last updated on Jun 21, 2021.
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The Staticin brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.
For Dermatologic Use Only. Not for Ophthalmic Use.
Staticin Description
Staticin® (erythromycin topical solution) 1.5% contains erythromycin for topical dermatologic use. Erythromycin is a macrolide antibiotic produced from a strain of Saccaropolyspora erythraea (formerly Streptomyces erythreus). It is a base and readily forms salts with acids.
Chemically, erythromycin is C37H67NO13. It has the following structural formula:
Erythromycin has the molecular weight of 733.94. It is a white to grayish white or pale yellow crystalline powder.
Each mL of Staticin contains 15 milligrams of erythromycin in a base of 55% alcohol, fragrance, laureth-4, and propylene glycol.
Staticin - Clinical Pharmacology
The exact mechanism by which erythromycin reduces lesions of acne vulgaris is not fully known; however, the effect appears to be due in part to the antibacterial activity of the drug.
MICROBIOLOGY
Erythromycin acts by inhibition of protein synthesis in susceptible organisms by reversibly binding to 50 S ribosomal subunits, thereby inhibiting translocation of aminoacyl transfer-RNA and inhibiting polypeptide synthesis. Antagonism has been demonstrated in vitro between erythromycin, and lincomycin, chloramphenicol, and clindamycin.
Indications and Usage for Staticin
Staticin is indicated for the topical treatment of acne vulgaris.
Contraindications
Staticin is contraindicated in those individuals who have shown hypersensitivity to any of...
