Sylvant
Generic name:siltuximab [ sil-TUX-i-mab ]
Drug class:Interleukin inhibitors
What is Sylvant?
Sylvant inhibits a certain protein in the body called interleukin-6 (IL-6). High levels of IL-6 can cause an overgrowth of cells in the lymph system (part of your immune system).
Sylvant is used to treat Multicentric Castleman's Disease (MCD). MCD is a rare condition in which the body produces too much of a certain type of white blood cell. MCD can increase your risk of certain cancers by changing the way your immune system works.
Sylvant is not for use in people who have human immunodeficiency virus (HIV) or human herpesvirus-8.
Warnings
You should not use Sylvant if you have a severe infection. Tell your doctor if you have recently had any signs of infection (fever, chills, body aches).
Before taking this medicine
You should not be treated with Sylvant if you are allergic to siltuximab, or if you have a severe infection.
If you have a severe illness with fever or any type of infection, you may need to wait until you get better before receiving this medicine. Tell your doctor if you have recently had any signs of infection (fever, chills, body aches).
To make sure Sylvant is safe for you, tell your doctor if you have ever had:
a chronic infection;
a stomach or intestinal disorder, including ulcer or diverticulitis;
stomach or intestinal bleeding;
gout; or
if you have recently received any vaccines, or if you are due to receive one.
Sylvant may harm an unborn baby. Siltuximab an affect the immune system of a newborn if the mother receives the medicine during pregnancy. Uee effective birth control to prevent pregnancy while you are using this medicine and for at least 3 months after your last dose.
You should not breast-feed while using this medicine.
How is Sylvant given?
Sylvant is given as an infusion into a vein, usually once every 3 weeks. A healthcare provider will give you this injection. Follow your doctor's dosing instructions very carefully.
Before each injection, your doctor may perform blood tests to make sure you do not have conditions that would prevent you from safely using Sylvant.
Siltuximab can increase your risk of bleeding or infection. You will need frequent medical tests. Your treatments may be delayed based on the results.
Sylvant must be given slowly and the IV infusion can take at least 1 hour to complete.
Siltuximab can lower blood cells that help your body fight infections. Your blood will need to be tested often. Your treatments may be delayed based on the results of these tests.
Dosing information
Usual Adult Dose for Castleman's Disease:
11 mg/kg intravenously over 1 hour every 3 weeks.
Duration of therapy: Until treatment failure.
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