Symax Duotab

Generic name:hyoscyamine sulfate
Dosage form: tablet, multilayer, extended release
Drug class:Anticholinergics / antispasmodics

Medically reviewed by Drugs.com. Last updated on Sep 1, 2021.

Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. Read further information about unapproved drugs.

Symax Duotab Description

Each purple and white, biphasic, capsule shaped tablet for oral administration is specially formulated to release 0.125 mg of hyoscyamine sulfate immediately and 0.250 mg hyoscyamine sulfate over the remaining 8 to 12 hours of the dosing period.

Hyoscyamine sulfate is one of the principal anticholinergic/antispasmodic components of belladonna alkaloids.

Hyoscyamine sulfate is Benzeneacetic acid, α-(hydroxymethyl)-, 8- methyl-8-azabicyclo[3.2.1]oct-3-yl ester, [3( S)- endo]-, sulfate (2:1), dihydrate.

(C 17H 23NO 3) 2 • H 2SO 4 • 2H 2O M.W. 712.85

INACTIVE INGREDIENTS

Inactive ingredients include calcium phosphate, D&C Red #30, FD&C Blue #1, lactose monohydrate, magnesium stearate, methylcellulose, povidone, silicified microcrystalline cellulose, and sodium starch glycolate.

Symax Duotab - Clinical Pharmacology

Symax ® Duotab inhibits specifically the actions of acetylcholine on structures innervated by postganglionic cholinergic nerves and on smooth muscles that respond to acetylcholine but lack cholinergic innervation. These peripheral cholinergic receptors are present in the autonomic effector cells of the smooth muscle, the cardiac muscle, the sinoatrial node, the atrioventricular node, and the exocrine glands. At therapeutic doses, it is completely devoid of any action on autonomic ganglia. Symax ® Duotab inhibits gastrointestinal propulsive motility and decreases gastric acid secretion.

Symax ® Duo...