Symproic

Generic name:naldemedine [ nal-DEM-e-deen ]
Drug class:Peripheral opioid receptor antagonists

Medically reviewed by Philip Thornton, DipPharm. Last updated on Apr 26, 2022.

What is Symproic?

Symproic blocks certain effects of opioid medication. An opioid is sometimes called a narcotic.

Symproic reduces constipation caused by opioid pain medicine used to treat severe chronic pain. Naldemedine works by treating constipation without reducing the pain-relieving effects of the narcotic.

Symproic as been shown to be effective in people who have taken opioid pain medicines (for at least 4 weeks) to treat chronic pain that is not caused by cancer.

Warnings

You should not use Symproic if you have a blockage in your stomach or intestines.

Stop using Symproic and call your doctor at once if you have severe stomach pain that does not go away (this can lead to serious medical problems).

Tell your doctor if you have symptoms of opioid withdrawal, such as sweating, feeling hot or cold, tremors, fast heartbeats, agitation, runny nose, watery eyes, vomiting, and diarrhea.

Naldemedine may be habit-forming. Never share this medicine with another person. MISUSE OF HABIT-FORMING MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH.

Before taking this medicine

You should not use Symproic if you are allergic to naldemedine, or if you have:

• a blockage in your stomach or ...